CO-CULTURE SIMPLIFIED
CO-CULTURE SIMPLIFIED
Onexio’s innovative microplate technology allows co-culture via micro-scale diffusion channels between pairs of wells. This patented design facilitates improved assay relevance in HTS. Established uses include integrating drug metabolism and other intercellular interactions in a technically simple format for drug/chemical safety and discovery applications. The microDUO design is easily scaled (i.e., 96, 384, 1536-well plate formats and 48, 192 and 768 co-culture assays per plate respectively) in a ANSI/SLAS format that seamlessly integrates into existing automated HTS workflows. Co-culture can easily be initiated and reversed by the addition or removal of media, respectively. The wells in the microDUO plate can have clear or solid bottoms, allowing a range of assay endpoints on both cell types, (e.g., fluorescence, luminescence, or absorbance) to be measured by a standard plate reader or high-content imager. The microDUO offers a user-friendly assay set-up and while other technologies require extensive handling, equipement and unique expertise, the microDUO only requires the same level of operational knowledge needed for a standard microplate. The microDUO plate has been designed to be a cost-effective alternative to traditional co-culture platforms.
Onexio’s innovative microplate technology allows co-culture via micro-scale diffusion channels between pairs of wells. This patented design facilitates improved assay relevance in HTS. Established uses include integrating drug metabolism and other intercellular interactions in a technically simple format for drug/chemical safety and discovery applications. The microDUO design is easily scaled (i.e., 96, 384, 1536-well plate formats and 48, 192 and 768 co-culture assays per plate respectively) in a ANSI/SLAS format that seamlessly integrates into existing automated HTS workflows. Co-culture can easily be initiated and reversed by the addition or removal of media, respectively. The wells in the microDUO plate can have clear or solid bottoms, allowing a range of assay endpoints on both cell types, (e.g., fluorescence, luminescence, or absorbance) to be measured by a standard plate reader or high-content imager. The microDUO offers a user-friendly assay set-up and while other technologies require extensive handling, equipement and unique expertise, the microDUO only requires the same level of operational knowledge needed for a standard microplate. The microDUO plate has been designed to be a cost-effective alternative to traditional co-culture platforms.
Onexio Biosystems is developing a high-throughput (96, 384 and 1536 well) microplate platform that supports co-culture and multi-culture to improve human relevance in drug discovery and chemical toxicity testing applications. Known as the microDUO, this versatile platform technology supports the intercellular signaling necessary to improve human relevance, while maintaining full compatibility with standard HTS instrumentation.